Sesquiterpene lactones structural diversity and their biological activities free download as pdf file. Biological activities of sesquiterpene lactones isolated from. Screening of several biological activities induced by different sesquiterpene lactones isolated from centaurea behen l. Biological activity sesquiterpene lactones have a distinctive biological activity. Pdf antitrypanosomal sesquiterpene lactones from saussurea.
In vitro leishmanicidal activities of sesquiterpene lactones. Sesquiterpene lactones are natural stereochemically pure compounds, which show a number of biological activities. Fourteen new compounds of this series belonging to the germacranolides, eudesmanolides, guaianolides, and pseudogermanolides have. The relationship between chemical structure and cytotoxic activity of ses quiterpene lactones was investigated in many papers on numerous tumour models. Experts in different fields have been invited to contribute on this class of compounds chemistry, isolati. Biological activity of flavonoids and rare sesquiterpene. Naturally occurring sesquiterpene lactones and their semi.
Synergistic antimycobacterial activities of sesquiterpene. The activity is connected to presence of, unsaturated lacton ring 7. They are fifteen carbon compounds formed from condensation of three isoprene units, followed by cyclization and oxidative transformation to make a cis or transfused lactone. Particularly, sesquiterpenoids that possess a lactone ring, precisely called sesquiterpene lactones sls, have raised attention in the medicinal chemistry field, due to their numerous biological activities, also known before the socalled modern medicine. A number of plants from the inula genus have rich source of sesquiterpenoids and is famous for its diverse biological activities. Identification of a novel sesquiterpene biosynthetic.
Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of asteraceae family, with over 5000 structures reported to date. Structural investigation and biological activity of. Asteraceae article in current pharmaceutical design 23999 february 2017 with 210 reads how we measure. This paper will summarize current knowledge about sesquiterpene lactones in plants. Chemical constituents and biological activities of artemisia. Centaurea, sesquiterpene lactones, dna, cell viability, toxicity, glutathione. Investigations of chemical analyses and biological potential exhibited that flavonoids and sesquiterpene lactones, in particular germacranolides, eudesmanolides, elemanolides, and guaianolides, are compounds responsible for the biological potential of plants. Grienke u, radic brkanac s, vujcic v, urban e, ivankovic s, stojkovic r, rollinger jm, kralj j, brozovic a and radic stojkovic m 2018 biological activity of flavonoids and rare sesquiterpene lactones isolated from centaurea ragusina l. This book addresses chemical and biological aspects related to sesquiterpene lactones stls. In order to study the reactivity of sesquiterpene lactones in biological systems, we describe herein the asymmetric synthesis of a simple model, the methylene. Sesquiterpene lactones of iranian compositae family.
Within this family, genus artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Within this family, genus artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated. Biological activities of sesquiterpene lactones from. The present chapter will be highlighted on the recent developments on the sls and their diverse biological activities. They are known to poison livestock, to act as insect feeding deterrents and to cause allergic contact dermatitis in humans. Sesquiterpene lactones from plants of the family asteraceae. Hologram qsar studies of antiprotozoal activities of. They exert a broad range of activities, including antiinflammatory, antibacterial and anticancer properties. In addition, sesquiterpene lactones have anticarcinogenic, antiinflammatory capacity 63. An important usual feature of the sls is the presence of a. Five new sesquiterpene lactones, racemosalactones ae 15, along with 19 known sesquiterpene latones 624, were isolated from the roots of inula racemosa. Introduction sesquiterpene lactones sls constitute a large and diverse group of. Experts in different fields have been invited to contribute on this class of compounds chemistry, isolation and identification, biological activities antibacterial, antifungal, antiviral.
Sesquiterpene lactones constitute a large and diverse group of biologically active plant chemicals that possess antiinflammatory and antitumor activity 1. Kolodziej and others published sesquiterpene lactone. All extracts were found to be more or less deter rent to the granary weevil beetle, the confused flour beetle, and larvae of the khapra beetle. The antimicrobial and cytotoxic activities of chloroform extracts from the weeds centaurea tweediei and c. Among other modifications, the incorporation of hydroxyls or esterified hydroxyls and epoxide ring are common. Promising biological activities of sesquiterpene lactones abstract.
Sesquiterpene lactones are one of the most prevalent and biologically significant classes of secondary metabolite present and hence have been subject to a number of studies. Constituents and biological activities of artemisia herbaalba 2 carbacholine induced contraction of guineapig trachea 6. Diverse biological activities of dandelion nutrition. Biological activities find, read and cite all the research you need on researchgate. Different stl subtypes have been reported as antileishmanial compounds. Biological activities of sesquiterpene lactones 259 pene lactones showed cytotoxic activity kb and p388 leukemia in vitro and activity against in vivo p388 leukemia 32. Pdf biological activities of sesquiterpene lactones. Biological activities of sesquiterpene lactones isolated from the. Sep 15, 2016 esterified drimanetype sesquiterpene lactones such as astellolides display various biological activities and are widely produced by plants and fungi. Review article sesquiterpene lactones from artemisia genus. Sesquiterpene lactones, produced in light and capable of inhibiting auxininduced elongation growth of coleoptile and hypocotyl segments, were isolated from young leaves of helianthus annuus spring and hager, planta in press, 1982. Sesquiterpene lactones belong to the large group of plant terpenoids. Sesquiterpene lactones sls are probably the largest class of secondary metabolites in plants, with over 5000 structures reported to date 1 4. Sesquiterpene lactones of the guaianolide and eudesmanolide types are considered to be of interest in treatment of gastric and peptic ulcers because they have an effect in the regulation and prevention of oxidative damage and inflammationmediated biological damage.
Pdf sesquiterpene lactones belong to the large group of plant terpenoids. As noted by numerous workers 26,28, the structures and reactivities of these sesquiterpene lactones fig. Pdf biological activities of sesquiterpene lactones eloy. Biological activities of sesquiterpene lactones sciencedirect. Sesquiterpene lactones chemical aspects biological activities adverse effects toxicity. Biological activity of flavonoids and rare sesquiterpene lactones. Sesquiterpene lactones sqls are an important group of bioactive compounds that are usu ally found in the asteraceae family, where they seem to be some of the most important con. In nature, sesquiterpene lactones play an important role in plant defense, as antibacterials. Biological activity of flavonoids and rare sesquiterpene lactones isolated from centaurea ragusina l. Antibacterial, antimicrobial and antiviral activity antimicrobial activity was recorded in tanacetopsis mucronata s. Artemisia species are popular plants which are used for the treatment of diseases such as hepatitis, cancer, inflammation and infections by fungi, bacteria, and viruses 7. Recent developments in the assessment of biological activities and structure relationships. The aim of this study was to determine the antimycobacterial potential of laurel oil, its fractions and its two sesquiterpene lactones against several mycobacterial strains and clinical isolates, and to establish the possibility of occurrence of some synergistic effects between those lactones using a modification of the fluorometric alamar blue microassay fmaba. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configuration of 2 was deduced from xray diffraction analysis.
These compounds have an antibiotic effect on gramnegative and grampositive bacteria as well as on some fungi. Oct 01, 2015 the present paper proposes an overview of biological activities and of methods used for the identification and quantification of sesquiterpene lactones found in artemisia genus. Sesquiterpene lactone composition of wild and cultivated. Across a broad range of helianthus annuus, differences in composition of sesquiterpene lactones extracted from disc florets were found between wild and cultivated sunflowers and also between distinct groups of inbreds used to produce sunflower hybrids. The main publications on this sesquiterpenolide, from its isolation of natural sources in 1972 to the current days, are included. Biological activities of sesquiterpene lactones isolated from the genus centaurea l.
Table 2 includes those sesquiterpene lactones that exhibit antitumor activity. Furthermore, the activity of sesquiterpene lactones may be due to the synergistic action of two specific sesquiterpene lactones identified from enriched ethyl acetate fractions. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Asteraceous plants are in turn the most diverse and. The results are generalized of the results of a study of 109 species of plants of the family compositae asteraceae growing on the territory of kazakhstan. In addition, a brief discussion on the applicability of geissmans rule for the sesquiterpene lactones, the probable reason for the presence of chlorine. Sesquiterpene lactones posses a wide range of biological activities including plant growth regulating, insect antifeedant, antibacterial, cytotoxic. Sesquiterpene lactones sqls are an important group of bioactive compounds that are usually found in the asteraceae family, where they seem to be some of the most important constituents for defense against microorganisms. They were tested for in vitro antitrypanosomal activities and cytotoxicity alongside the structurally keywords.
Sesquiterpene lactones structural diversity and their. In nature, sesquiterpene lactones play an important role in plant defense. Biological activities and methods of analysis biancaivanescu,1 ancamiron,2 andandreiacorciova3. Sep 01, 2012 hence, the sesquiterpene lactones in dandelion exert protective effects against acute hepatotoxicity induced by the administration of ccl 4 to mice. Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the asteracea family, are used in the traditional medicine of many countries for the treatment of various pathological conditions. Sesquiterpene lactones represent a group of compounds responsible for the. A highly stereoselective divergent synthesis of bicyclic. The potential for drug development from artemisia species continues to grow, particularly in the area of parasitic diseases and cancer treatment. The promising nature is shown of the search for biologically active sesquiterpene. Biological activities of sesquiterpene lactones 267 in the search for feeding deterrents of plant origin against selected storage pests, extracts of 11 species of composites were examined 156. Helenalin a sesquiterpene lactone with multidirectional. Biological activities and methods of analysis biancaivanescu, 1 ancamiron, 2 andandreiacorciova 3 department of pharmaceutical botany, faculty of pharmacy, university of medicine and pharmacy grigore t.